Labmonk quiz, NET Life Science,
#1. Monoclonal antibodies (mAb) can be potentially used as therapeutic agents. The major advantage is that they can specifically target aberrant cells. However, there is a practical difficulty. Monoclonals are raised in mouse and therefore it is expected that an immune reaction will develop if these are injected into humans. It is therefore necessary to humanize monoclonal antibody by
#2. In amphibian oocyte, the germplasm which gets segregated during cleavage to give rise to primordial germ cells (PGCs) is normally
#3. Mouse bone marrow cells were fractionated to derive stem cell antigen-1+ (Sca-1+) cells. These cells were cultured with interleukin-3, or granulocyte-macrophage colony stimulating factor, or macrophage-colony stimulating factor, or granulocyte colony stimulating factor. Most numerous and varied colonies were obtained in the culture stimulated with
#4. Macrophages were collected from BALB/c mice, CD40-deficient mice, CD86-deficient mice and ICAM-1-deficient mice. These macrophages were co-cultured with LCMV peptide-specific T cells in presence of the LCMV peptide for three days. The cells were recovered and co-cultured with BALB/c-derived macrophages in presence of the peptide. During the last twelve hour of the co-culture, 3H-thymidine was added to the cultures. The cells were harvested and 3H-thymidine incorporation was assessed. The highest incorporation was observed in
#5. A patient undergoes liver transplantation and during post-operative treatment, becomes susceptible to infection. The patient can be treated in two different modes and can have alternative outcomes. Which of the following statement is correct?
#6. Toll-like receptor 4 is associated with responsiveness to LPS, an endotoxin that causes lethal endotoxic shock. The mice deficient in Toll-like receptor 4 and BALB/c mice were injected with Escherichia coli. In addition, some BALB/b mice were also injected with the same bacteria alone or with anti-interleukin-10 (IL-10) antibody. The mice resistant to the lethal effect of the bacteria were
#7. Intracellular pathogens like Mycobacteria, Salmonella, Leishmania and Listeria survive in macrophages by modulating host cellular machinery. In order to study the fate of these intracellular pathogens in macro-phages, cells were labelled with lysotracker Red and infected with GFP-labelled organisms. After 2 hours at 37°C, cells were fixed, stained with anti-transferrin receptor antibody and probed with secondary antibody conjugated-blue dyes. Cells were viewed under confocal microscope. Observation: GFP-labelled Mycobacteria, Salmonella and Listeria were localized in the same compartment labelled with blue dyes, whereas GFP-Leishmania colocalize with red labelled compartment. Which of the following statement is true based on these observations?
#8. Cytoplasmic determinants coding for anterior structure of Drosophila embryo, if injected elsewhere in the recipient embryo, would lead to
#9. Glucose is mobilized in muscle when epinephrine activates GSα. In an experiment in which muscle cells were stimulated with epinephrine, glucose mobilization was observed even after withdrawal of epinephrine. This could be
#10. Cancer causing genes can be functionally classified into mainly three types: 1. genes that induce cellular proliferation 2. tumor suppressor genes 3. genes that regulate apoptotic pathway Epstein-Barr virus that causes cancer by modulating apoptotic pathway, contains a gene having sequence homology with which of the following genes?
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