Quiz 12-January-2023

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#1. Appropriate reasons for the deviation from the beer’s law among the following are (P) Monochromaticity of light (Q) Very high concentration of analyte (R) Association of analyte (S) Dissociation of analyte

P, Q and S

P, Q and S

P, Q and R

P, Q and R

Q, R, and S

Q, R, and S

P, R and S

P, R and S

#2. Which of the ultrashort acting adrenergic blocker

Carvedilol

Carvedilol

Atenolol

Atenolol

Acebutolol

Acebutolol

Esmolol

Esmolol

#3. When the angle of repose exceeds……………, the powder flow is rarely acceptable for pharmaceutical manufacturing purpose

50

50

30

30

60

60

25

25

#4. Drugs that show nonlinear pharmacokinetics have which of the following property

A constant ratio of drug metabolites is formed as the administered dose increase.

A constant ratio of drug metabolites is formed as the administered dose increase.

The steady state drug concentration increases in direct proportion to the dosing rate

The steady state drug concentration increases in direct proportion to the dosing rate

The elimination half – life increasing as the administered dose increase

The elimination half – life increasing as the administered dose increase

The area under the plasma drug concentration versus time curve increasing in direct proportion to an increase in the administered dose.

The area under the plasma drug concentration versus time curve increasing in direct proportion to an increase in the administered dose.

Both low and high doses follow first order elimination kinetics

Both low and high doses follow first order elimination kinetics

#5. Which one of the following is used in the Ames test

Salmonella typhimurium

Salmonella typhimurium

Streptococcus aureus

Streptococcus aureus

E. coli

E. coli

Pseudomonas aeruginosa

Pseudomonas aeruginosa

#6. Le Chatelier’s principle states that increasing temperature favours a reaction that………..

Release energy as heat

Release energy as heat

Gluconeogenesis

Gluconeogenesis

Involves a chemical catalyst

Involves a chemical catalyst

Requires energy as heat

Requires energy as heat

#7. An alternative to glycolysis pathway is…………..

Citric acid cycle

Citric acid cycle

Pentose phosphate pathway

Pentose phosphate pathway

Gluconeogenesis

Gluconeogenesis

Glyoxylate pathway

Glyoxylate pathway

#8. Match the following biochemical transformations with coenzymes involved (i) α–Ketoglutarate to glutamic acid (ii) Uridine to thymidine (iii) Pyruvic acid to acetyl coenzyme A (a) Tetrahydrofolate (b) NADH (c) Thiamine pyrophosphate (d) Pyridoxamine

(a) i-d, ii-a, iii-c

(a) i-d, ii-a, iii-c

(c) i-b, ii-a, iii-c

(c) i-b, ii-a, iii-c

(b) i-a, ii-b, iii-d

(b) i-a, ii-b, iii-d

(d) i-d, ii-b, iii-c

(d) i-d, ii-b, iii-c

#9. In absorption spectrometry, high values of absorbance values (greater than 1 or 2) tend to give poorer precision because

Little light reaches the detector

Little light reaches the detector

Beer’s law deviations are worse

Beer’s law deviations are worse

Monochromators work poorly under intense light

Monochromators work poorly under intense light

Too much light saturates the detector

Too much light saturates the detector

#10. Drugs that have been found to be useful in one or more types of heart failure include all the following EXCEPT……………

ACE inhibitors

ACE inhibitors

Adrenoceptor agonist

Adrenoceptor agonist

Adrenoreceptor agonists and antagonists

Adrenoreceptor agonists and antagonists

Na+/K+ ATPase inhibitors

Na+/K+ ATPase inhibitors

Finish

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