Preparation of various types suspensions and determination of their sedimentation parameters

Rate this post

[ps2id id=’background’ target=”/]

BACKGROUND

Mg. Carbonate is an insoluble but diffusible solid. In flocculated suspension, the practical settle more quickely than practical of deflocculated one. But the sediments from a cake like structure in deflocculated suspension making dispersibility on shaking a big problem compairing these 2 types of suspension,the flocculated one is pharmaceutically acceptable or preferable however,a control flocculation is desirable to achive a control sedimentation with ease of dispersibility.1,2

Electrolyte and ionic surfactant can be used as flocculating agents to produce a flocculated suspension.suspension prepared without flocculating agent is a deflocculated one.

The physical stability of the suspension is assist by determining the sedimentation volume or degree of flocculation.

Aim: To prepare a flocculated and deflocculated suspension of mg.carbonate and assess their stability.

[ps2id id=’requirements’ target=”/]

REQUIREMENTS

Materials and apparatus:      Mg.carbonate,

Al.chloride,

Water,

Pastle and mortar

Measuring cylinder.

[ps2id id=’procedure’ target=”/]

PROCEDURE

Step-1: Preparation of suspension

Deflocculated suspension

1. The light magnesium carbonate is powered in a mortar.

2. The water is added with trituration to make a cream and diluted sufficiently.

3. Then it is transferred to a measuring cylinder. The mortar is repeatedly rinsed with little water every time and the rinsed mixture is added subsequently to adjust the volume.

Floculated suspension

1 . The light magnesium carbonate is powered in mortar.

2. Aluminium chloride is dissolved in little water and added with trituration to make a cream. The cream is transferred to the measuring cylinder after dilution of water .

3. The mortar is repetedly rinsed with little amount of water every time and the rinsed mixture is added subsequently to adjust the volume.

Step-2 Evaluation of suspension

1 . The suspension in the cylinders are thoroughly shaken to make the dispersions uniform.

2. The cylinders are kept undisturbed on a flat surface after shaking .

3. The volume of sediment at different time: 0,10,30,45,and 60 mins is measured.

Original volume of suspension is 100 ml

The degree of flocculation at one hr=sediment volume of flocculated suspension in one hour/sediment volume of deflocculated volume in one hour.3

(Though degree of flocculation is related to the ultimate sediment volume in flocculated and deflocculated suspension, it is not feasible to achieve or determine ultimate volume with in the practical period.)

The plot of sedimentation volume in Y axis and time in X axis.

(Sedimentation volume quickly decrease in flocculated suspension compared to deflocculated suspension initially but ultimate sedimentation volume of flocculated will be higher)

Time in minute

Volume of sediment for flocculated suspension in ml

Sedimentation volume for flocculated suspension

Volume of sediment for deflocculated suspension in ml

Sedimentation volume for deflocculated suspension

0

10

30

45

60

[ps2id id=’conclusion’ target=”/]

CONCLUSION

The flocculated and deflocculated suspension is prepared and evaluated for sedimentation volume.

[ps2id id=’references’ target=”/][ps2id id=’1′ target=”/]

REFERENCES

  1. More HN, Hajare AA. Practical Physical Pharmacy. Career Publications. 2010: 203-205.
  2. Gaud RS, Gupta GD. Practical Physical Pharmacy. CBS Publisher and Distributors. 2009: 81-84
  3. Mohanta GP. Physical Pharmacy Practical Text, Pharma Book Syndicate. 2006: 72-74.