Determination of alcohol-soluble extractive value of Ginger

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BACKGROUND

Extractive values are used for evaluation of crude drugs when they cannot be estimated by any other method. Extractive values by different solvents are used to assess quality, purity and to detect adulteration due to exhausted and incorrectly processed drugs.1

Crude drugs contain a number of constituents and these have a selective solubility in different solvents. Water, alcohol, alcohol/water mixtures, generally 45%, 60%, 90% ethanol, ether are used as solvents to prepare ethanol soluble extractive, water soluble extractive (chloroform water), ether soluble extractive, etc.

Extractive values indicate the presence of different constituents and TLC fingerprints can be developed for identification and semi-quantitative analysis from these extracts.

Ginger contains about 1-3 % volatile oil and 5-8 % resins, which are soluble in alcohol.

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REQUIREMENTS

Alcohol soluble extractive of ginger (should not be less than 4.5 %. Lower values indicate exhausted ginger with alcohol. Ginger exhausted with alcohol passes this test).

250 ml conical flask with stopper

Alcohol (90%)

Shallow flat-bottomed dish

Water bath

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PROCEDURE

  1. Weigh accurately about 5 g of coarsely powdered drug into a 250 ml conical flask with stopper.
  2. Add 100 ml of alcohol (90%).
  3. Shake the flask frequently during first 6 hr.
  4. Keep it aside without disturbing for 18 hr. and then filter.
  5. Pipette out 25 ml of the filtrate and evaporate to dryness in a weighed shallow flat-bottomed dish on a water bath.
  6. Then dry the residue at 1050 C to a constant weight.
  7. Calculate the percentage of alcohol-soluble extractive.
  8. % of alcohol soluble extractive = weight of residue/weight of the drug x 100

It is expressed as percent w/w of the air-dried drug.

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CONCLUSION

Water-soluble extractive value of Ginger is ____.

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REFERENCES

  1. Joshi S, Aeri V. Practical Pharmacognosy, 1st edition, Frank Bros. & Co. New Delhi; 2009: 255.